| 09/11/2021 | DC United | NE Revolution | 10:15AM - 11:15AM | Echelon Complex / Echelon 5 Turf | |
| 09/11/2021 | Houston Dynamo | Philadelphia Union | 11:30AM - 12:30PM | Echelon Complex / Echelon 5 Turf | |
| 09/18/2021 | NE Revolution | Houston Dynamo | 1:00PM - 2:00PM | Echelon Complex / Echelon 3 | |
| 09/18/2021 | Philadelphia Union | DC United | 2:15PM - 3:15PM | Echelon Complex / Echelon 3 | |
| 09/23/2021 | Philadelphia Union | NE Revolution | 7:15PM - 8:15PM | Echelon Complex / Echelon 3 | |
| 09/25/2021 | Houston Dynamo | Philadelphia Union | 11:30AM - 12:30PM | Echelon Complex / Echelon 3 | |
| 09/25/2021 | NE Revolution | DC United | 1:00PM - 2:00PM | Echelon Complex / Echelon 3 | |
| 09/28/2021 | DC United | Houston Dynamo | 7:15PM - 8:15PM | Echelon Complex / Echelon 3 | |
| 10/02/2021 | DC United | Philadelphia Union | 9:00AM - 10:00AM | Echelon Complex / Echelon 6 Turf | |
| 10/02/2021 | NE Revolution | Houston Dynamo | 10:15AM - 11:15AM | Echelon Complex / Echelon 6 Turf | |
| 10/05/2021 | Philadelphia Union | NE Revolution | 6:00PM - 7:00PM | Echelon Complex / Echelon 3 | |
| 10/05/2021 | Houston Dynamo | DC United | 7:15PM - 8:15PM | Echelon Complex / Echelon 3 | |
| 10/09/2021 | Houston Dynamo | Philadelphia Union | 11:30AM - 12:30PM | Echelon Complex / Echelon 6 Turf | |
| 10/09/2021 | DC United | NE Revolution | 1:00PM - 2:00PM | Echelon Complex / Echelon 6 Turf | |
| 10/16/2021 | NE Revolution | Houston Dynamo | 11:30AM - 12:30PM | Echelon Complex / Echelon 5 Turf | |
| 10/16/2021 | Philadelphia Union | DC United | 1:00PM - 2:00PM | Echelon Complex / Echelon 5 Turf | |
| 10/23/2021 | Philadelphia Union | NE Revolution | 9:00AM - 10:00AM | Echelon Complex / Echelon 6 Turf | |
| 10/23/2021 | DC United | Houston Dynamo | 10:15AM - 11:15AM | Echelon Complex / Echelon 6 Turf | |
| 10/30/2021 | Houston Dynamo | Philadelphia Union | 2:15PM - 3:15PM | Echelon Complex / Echelon 3 | |
| 10/30/2021 | NE Revolution | DC United | 3:30PM - 4:30PM | Echelon Complex / Echelon 3 | |